Salt, inflammation, IL‐17 and hypertension

Interactions between oxidative stress and inflammation in salt-sensitive hypertension.

The goal of this study was to test the hypothesis that increases in oxidative stress in Dahl S rats on a high-salt diet help to stimulate renal nuclear factor-kappaB (NF-kappaB), renal proinflammatory cytokines, and chemokines, thus contributing to hypertension, renal damage, and dysfunction. We specifically studied whether antioxidant treatment of Dahl S rats on high Na intake would decrease r...

Recent Advances in Neurogenic Hypertension: Dietary Salt, Obesity, and Inflammation.

Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions Mohan K. Raizada, Bina Joe, Nathan S. Bryan, Eugene B. Chang, Floyd E. Dewhirst, Gary G. Borisy, Zorina S. Galis, Wendy Henderson, Pedro A. Jose, Christian J. Ketchum, Johanna W. Lampe, Carl J. Pepine, Jennifer L. Pluznick, Dominic Ra...

Salt handling and hypertension.

The kidney plays a central role in our ability to maintain an appropriate sodium balance, which is critical for the determination of blood pressure. The kidney's capacity for salt conservation may not be widely appreciated, and in general we consume vastly more salt than we need. Here we consider the socioeconomics of salt consumption, outline current knowledge of renal salt handling at the mol...

Dietary Salt Intake and Hypertension

Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities. Moderate reduction of dietary salt intake is generally an effective measure to reduce blood pressure. However, recently some in the academic society and lay media dispute the benefits of salt restriction, pointing to inconsistent outcomes noted in s...

Salt Sensitive Hypertension and Orexin